Metabolism Alprazolam is thoroughly metabolized in humans, principally by cytochrome P450 3A4 (CYP3A4), to 2 key Energetic metabolites from the plasma: four-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation amounts of the two active metabolites are below 4% in the dad or mum. The described relative potencies in benzodiazepine recept